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Title: Mechanism of anticancer effects of antimicrobial peptides
Authors: Liu, X
Li, Y 
Li, Z
Lan, XQ
Leung, PHM 
Li, JS
Yang, M
Frank, K
Qin, L
Keywords: Antimicrobial peptides
Anticancer activity
Electrostatic Attraction
Hydrophobic Interaction
Anticancer Drug Resistance
Issue Date: 2014
Publisher: Textile Bioengineering & Informatics Society Ltd
Source: Textile bioengineering and informatics symposium proceedings, 2014, vols 1 and 2, 2014, p. 243-251 How to cite?
Abstract: Antimicrobial peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contributed to the potential mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective targeting properties made AMPs promising candidates for alternative approach to solve the problems from anticancer drug resistance.
Description: 7th Textile Bioengineering and Informatics Symposium (TBIS 2014) / 5th Asian Protective Clothing Conference (APCC 2014), Hong Kong, Peoples R China, 6-8 August 2014
ISSN: 1942-3438
Appears in Collections:Conference Paper

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