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Title: Outcomes of adjuvant endocrine therapy and hormone receptor status change following neoadjuvant chemotherapy in breast cancer patients
Authors: Wu, JY
Chen, WG
Chen, XS
Huang, O
He, JR
Zhu, L
Li, Y
Shen, KW
Chow, LWC
Loo, WTY
Chow, CYC
Tsang, W 
Keywords: Breast cancer
Endocrine therapy
Hormone receptor
Neoadjuvant chemotherapy
Issue Date: 2014
Publisher: Wichtig Editore
Source: International journal of biological markers, 2014, v. 29, no. 4, p. e380-e386 How to cite?
Journal: International journal of biological markers 
Abstract: Background: This retrospective study investigated the therapeutic benefit of adjuvant endocrine therapy (ET) in breast cancer patients with hormone receptor (HR) status change from positive to negative after neoadjuvant chemotherapy (NAC).
Methods: From December 2000 to November 2010, 97 eligible patients with a positive-to-negative switch of HR status after NAC were identified. All patients were categorized into 2 groups on the basis of the administration of ET: 57 ET-administered patients and 40 ET-naïve patients. Survival analyses were performed to examine the prognostic value of ET administration as well as other clinical and pathologic variables.
Results: The administration of ET was significantly associated with improved disease-free survival (p=0.018) in patients with a positive-to-negative switch of HR status. The 5-year disease-free survival rates were 77.0% and 55.5%, respectively, in ETadministered patients and ET-naïve patients. The 5-year overall survival rate for ET-administered patients was also higher than that of ET-naïve patients (81.3% vs. 72.7%, p=0.053), albeit this was statistically insignificant.
Conclusions: This study revealed that patients with HR altered from positive to negative after NAC still benefit from ET. The HR status should be evaluated not only in specimens obtained during post-NAC surgery but also in specimens biopsied before NAC.
ISSN: 0393-6155
DOI: 10.5301/jbm.5000113
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