Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/35002
Title: Aminophosphine phosphinites derived from chiral 1,2-diphenyl-2-aminoethanols : synthesis and application in rhodium-catalyzed asymmetric hydrogenation of dehydroamino acid derivatives
Authors: Lou, R
Mi, A
Jiang, Y
Qin, Y
Li, Z
Fu, F
Chan, AS
Keywords: Aminophosphine phosphinite
Dehydroamino acid derivative
Asymmetric hydrogenation
Issue Date: 2000
Publisher: Elsevier
Source: Tetrahedron, 2000, v. 56, no. 32, p. 5857-5863 How to cite?
Journal: Tetrahedron
Abstract: A series of chiral aminophosphine phosphinites DPAMPPs was synthesized from optically active 1,2-diphenyl-2-aminoethanols. The erythro-DPAMPPs were found to serve as excellent ligands for rhodium-catalyzed asymmetric hydrogenation of dehydroamino acid derivatives. For an array of dehydroamino acid precursors, remarkably high enantioselectivity (up to 98.4% e.e.) and reactivity (the ratio of substrate/catalyst up to 10000) were observed. Some factors controlling the enantioselectivity were examined and discussed.
URI: http://hdl.handle.net/10397/35002
ISSN: 0040-4020
DOI: 10.1016/S0040-4020(00)00481-6
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