Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34982
Title: A novel impedance assay for cardiac myocyte hypertrophy sensing
Authors: Yang, M 
Zhang, X
Keywords: Impedance sensing
Cardiac hypertrophy
Endothelin-1 (ET-1)
Issue Date: 2007
Publisher: Elsevier
Source: Sensors and actuators A : physical, 2007, v. 136, no. 2, p. 504-509 How to cite?
Journal: Sensors and actuators A : physical
Abstract: Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.
URI: http://hdl.handle.net/10397/34982
ISSN: 0924-4247
DOI: 10.1016/j.sna.2006.09.014
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