Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34950
Title: Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue
Authors: Lam, KH
Lee, KKH
Gambari, R
Kok, SHL
Kok, TW
Chan, ASC
Bian, ZX
Wong, WY
Wong, RSM
Lau, FY
Tong, SW
Chan, KW
ChengCH
Chui, CH
Tang, JCO 
Keywords: Alkaloid analogues
Anti-tumour
Galipea longiflora
Issue Date: 2014
Publisher: Elsevier
Source: Phytomedicine, 2014, v. 21, no. 6, p. 877-882 How to cite?
Journal: Phytomedicine
Abstract: The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect.
URI: http://hdl.handle.net/10397/34950
ISSN: 0944-7113 (print)
DOI: 10.1016/j.phymed.2014.02.005
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