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Title: Wavelet coherence analysis of prefrontal oxygenation signals in elderly subjects with hypertension
Authors: Li, Z
Zhang, M 
Cui, R
Xin, Q
Liqian, L
Zhou, W
Han, Q
Gao, Y
Keywords: Near-infrared spectroscopy
Wavelet coherence
Phase coherence
Functional connectivity
Cerebral oxygenation
Spontaneous oscillations
Issue Date: 2014
Publisher: Institute of Physics Publishing
Source: Physiological measurement, 2014, v. 35, no. 5, p. 777-791 How to cite?
Journal: Physiological measurement 
Abstract: This study aims to assess the prefrontal functional connectivity in elderly subjects with hypertension during the resting state using wavelet coherence analysis of changes in prefrontal tissue oxyhaemoglobin concentrations (Δ[HbO2]) signals measured by near-infrared spectroscopy (NIRS). Continuous recordings of NIRS signals were obtained from the left and right prefrontal lobes in 24 elderly subjects with hypertension (age: 70.7 ± 8.4 years) and 26 elderly normotensive subjects (age: 70.6 ± 7.9 years) during the resting state. The coherence between the left and right prefrontal oscillations in four frequency intervals (I, 0.4 Hz to 2 Hz; II, 0.15 Hz to 0.4 Hz; III, 0.05 Hz to 0.15 Hz; and IV, 0.02 Hz to 0.05 Hz) was analyzed using wavelet coherence method. The Δ[HbO2] oscillations showed significant wavelet coherence (WCO) in intervals I and III, and significant wavelet phase coherence (WPCO) in intervals from I to IV. Remarkably, in elderly subjects with hypertension, the WCO and WPCO in interval III were significantly lower in the left and right prefrontal regions than in healthy elderly subjects (p = 0.014 for WCO, p = 0.007 for WPCO). The lower coherence in interval III indicates a decreased synchronization of neural control in the left and right prefrontal regions in elderly subjects with hypertension. This might suggest a weakened brain functional connectivity in the elderly subjects with hypertension.
ISSN: 0967-3334
DOI: 10.1088/0967-3334/35/5/777
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