Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34520
Title: d-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery
Authors: Lam, PLL
Kok, SHL
Bian, ZX
Lam, KH
Tang, JCO 
Lee, KKH
Gambari, R
Chui, CH
Keywords: Anti-cancer
Collagen
Calendula officinalis
D-glucose
Gelatin
Nanoparticles
Issue Date: 2014
Publisher: Elsevier
Source: Colloids and surfaces B : biointerfaces, 2014, v. 117, p. 277-283 How to cite?
Journal: Colloids and surfaces B : biointerfaces
Abstract: Gelatin/Collagen-based matrix and reservoir nanoparticles require crosslinkers to stabilize the formed nanosuspensions, considering that physical instability is the main challenge of nanoparticulate systems. The use of crosslinkers improves the physical integrity of nanoformulations under the-host environment. Aldehyde-based fixatives, such as formaldehyde and glutaraldehyde, have been widely applied to the crosslinking process of polymeric nanoparticles. However, their potential toxicity towards human beings has been demonstrated in many previous studies. In order to tackle this problem, d-glucose was used during nanoparticle formation to stabilize the gelatin/collagen-based matrix wall and reservoir wall for the deliveries of Calendula officinalis powder and oil, respectively. In addition, therapeutic selectivity between malignant and normal cells could be observed. The C. officinalis powder loaded nanoparticles significantly strengthened the anti-cancer effect towards human breast adenocarcinoma MCF7 cells and human hepatoma SKHep1 cells when compared with the free powder. On the contrary, the nanoparticles did not show significant cytotoxicity towards normal esophageal epithelial NE3 cells and human skin keratinocyte HaCaT cells. On the basis of these evidences, d-glucose modified gelatin/collagen matrix nanoparticles containing C. officinalis powder might be proposed as a safer alternative vehicle for anti-cancer treatments.
URI: http://hdl.handle.net/10397/34520
ISSN: 0927-7765 (print)
DOI: 10.1016/j.colsurfb.2014.02.041
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

11
Last Week
0
Last month
Citations as of Jun 25, 2017

WEB OF SCIENCETM
Citations

9
Last Week
0
Last month
Citations as of Jun 22, 2017

Page view(s)

27
Last Week
2
Last month
Checked on Jun 25, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.