Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34488
Title: Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines
Authors: Kok, SHL
Gambari, R
Chui, CH
Yuen, MCW
Lin, E
Wong, RSM
Lau, FY
Cheng, GYM
Lam, WS
Chan, SH
Lam, KH
Cheng, CH
Lai, PBS
Yu, WY 
Cheung, F
Tang, JCO 
Chan, ASC
Keywords: Antiproliferation
Benzothiazole
Neoplasm
Phthalimide
Issue Date: 2008
Publisher: Elsevier
Source: Bioorganic & medicinal chemistry, 2008, v. 16, no. 7, p. 3626-3631 How to cite?
Journal: Bioorganic & medicinal chemistry
Abstract: Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the ‘one pot’ condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.
URI: http://hdl.handle.net/10397/34488
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2008.02.005
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