Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34426
Title: Association of the Asporin D14 Allele with lumbar-disc degeneration in Asians
Authors: Song, YQ
Cheung, KMC
Ho, DWH
Poon, SCS
Chiba, K
Kawaguchi, Y
Hirose, Y
Alini, M
Grad, S
Yee, AFY
Leong, JCY
Luk, KDK
Yip, SP 
Karppinen, J
Cheah, KSE
ShamP
Ikegawa, S
Chan, D
Issue Date: 2008
Publisher: Elsevier
Source: American journal of human genetics, 2008, v. 82, no. 3, p. 744-747 How to cite?
Journal: American journal of human genetics
Abstract: Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
URI: http://hdl.handle.net/10397/34426
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2007.12.017
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