Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34376
Title: In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B
Authors: Zhao, Z
Gambari, R
Lee, KKH
Kok, SHL
Wong, RSM
Lau, FY
Tang, JCO 
Lam, KH
Cheng, CH
Hau, DKP
Chui, CH
Wong, WY
Wong, WK
Keywords: Amphiphilic silicon(IV) phthalocyanine
Anticancer drugs
Hep3B
Nude mice xenograft
Rhodamine B
Toxicity
Issue Date: 2013
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry letters, 2013, v. 23, no. 8, p. 2373-2376 How to cite?
Journal: Bioorganic & medicinal chemistry letters 
Abstract: We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.
URI: http://hdl.handle.net/10397/34376
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2013.02.049
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