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Title: A lipid extract of Perna canaliculus affects the expression of pro-inflammatory cytokines in a rat adjuvant-induced arthritis model
Authors: Lee, CH
Butt, YKC
Wong, MS 
Lo, SCL 
Keywords: Adjuvantinduced arthritis
Pro-inflammatory cytokines
Issue Date: 2008
Source: European annals of allergy and clinical immunology, 2008, v. 40, no. 4, p. 148-153 How to cite?
Journal: European Annals of Allergy and Clinical Immunology 
Abstract: As published initially in this same journal in 2000 (1), the lipid extract of Perna canaliculus (New Zealand green-lipped mussel; Lyprinol®) is known for its anti-inflammatory effects in animal models and in human controlled studies (arthritis; asthma). As a follow-up of its effects on pain in a rat model of adjuvant-induced arthritis (AIA) (2), we studied its effects on the production of cytokines known to be associated with inflammation (IL-6, IL-lα. TNF-α, IFN-γ). Feeding with Lyprinol was associated with significantly decreased expression levels of TNF-α and IFN-γ when compared to Naproxen (positive control) and, even more when compared with sham and extra-virgin olive oil (negative control). When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-lα. were also marginally decreased in rats fed with Lyprinol. This study demonstrates that AIA rats fed with Lyprinol had decreased production of cytokines associated with inflammation.
ISSN: 0397-9148
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