Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34241
Title: Synthesis of novel diastereomeric diphosphine ligands and their applications in asymmetric hydrogenation reactions
Authors: Qiu, L
Qi, J
Pai, CC
Chan, S
Zhou, Z
Choi, MCK
Chan, ASC
Issue Date: 2002
Publisher: American Chemical Society
Source: Organic letters, 2002, v. 4, no. 26, p. 4599-4602 How to cite?
Journal: Organic letters 
Abstract: (Matrix Presented) Diastereomeric biaryl diphosphine ligands 10 and 11 with added chiral centers on the backbone were synthesized. Substrate-directed asymmetric synthesis occurred in the coupling step of the preparation of the diastereomeric diphosphine oxides. The diastereomeric diphosphine oxides were easily separated by column chromatography with silica gel. Ruthenium catalysts containing these ligands were highly effective in the hydrogenation of 2-(6′-methoxy-2′-naphthyl)propenoic acid and β-ketoesters. The additional chiral centers had a significant influence on the enantioselectivity and activity of the catalysts.
URI: http://hdl.handle.net/10397/34241
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/ol026817+
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