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Title: Trabecular Bone Status in Ultradistal Tibia Under Habitual Gait Loading : a pQCT Study in Postmenopausal Women
Authors: Lai, YM 
Qin, L
Hung, VWY
Choy, WY
Chan, ST
Chan, LWC 
Chan, KM
Keywords: Bone loss
Mechanical adaptation
Postmenopausal women
Trabecular bone mineral density
Issue Date: 2006
Publisher: Elsevier Science Inc
Source: Journal of clinical densitometry, 2006, v. 9, no. 2, p. 175-183 How to cite?
Journal: Journal of Clinical Densitometry 
Abstract: This study investigated regional volumetric trabecular bone mineral density (tBMD) and bone area at the ultradistal tibia in Chinese women using peripheral quantitative computed tomography. Fifty-six postmenopausal women aged 47-62 yr participated in BMD measurements at baseline and 22 of them were followed at both 1-yr and 3-yr follow-up scans. Regional baseline tBMD, rate of annual bone loss, and trabecular bone area were determined. Baseline measurements showed that the tBMD of both the posterior (252.9 ± 63.4 mg/cm 3) and medial (226.6 ± 68.9 mg/cm 3) regions was significantly higher than that of the anterior (126.3 ± 61.9 mg/cm 3) and lateral regions (149.8 ± 50.6 mg/cm 3), respectively (p < 0.001). Both the 1-yr and 3-yr follow-up measurements showed that there was significant physiological annual tBMD loss on an average of 1.61%, at the four regions. Inter-slice regional tBMD and trabecular bone area measurements demonstrated a significant linear decrease from the distal to proximal aspects (p < 0.001). Findings suggest that dynamic compressive loading during the heel strike and the body weight vector shifting toward the medial aspect during the stance phase in a normal gait might account for the regional tBMD differences. Increased tBMD and bone area toward the distal tibial endplate may adapt to withstand the axial impact loading. However, the low-impact weight-bearing nature of a normal gait may not be osteogenic to prevent regional bone loss. An exercise program specific to the women at risk should be contemplated.
ISSN: 1094-6950
DOI: 10.1016/j.jocd.2005.11.006
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