Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34140
Title: Ultrastructural comparison of medial collateral ligament repair after single or multiple applications of GaAlAs laser in rats
Authors: Ng, GYF 
Fung, DTC
Leung, MCP
Guo, X 
Keywords: Collagen
Electron microscopy
Healing
Laser
Ligament
Issue Date: 2004
Source: Lasers in surgery and medicine, 2004, v. 35, no. 4, p. 317-323 How to cite?
Journal: Lasers in Surgery and Medicine 
Abstract: Background and Objectives: To examine single versus multiple applications of a gallium aluminum arsenide (GaAlAs) laser on the ultrastructural morphology of surgically injured medial collateral ligaments (MCLs) in rats. Study Design/Materials and Methods: Sixteen rats were studied with 12 receiving right MCL transection and 4 receiving sham injury. Group 1 (n = 4) received one session of laser (31.6 J/cm2) immediately after injury. Group 2 (n = 4) received 9 doses of transcutaneous laser (3.5 J/cm2). The controls (Group 3, n = 4) received one session of placebo laser, while the sham Group 4 (n = 4) received no treatment. Ultrastructural analyses were done with electron microscopy at 3 weeks. Results: The mass-averaged diameters of collagen fibril in the core and periphery of MCLs treated with multiple laser were larger than the control and those with single laser treatment (P < 0.05). However, the sham injured group had larger fibrils than all other groups (P < 0.05). Conclusions: The repairing MCLs had smaller collagen fibrils than the sham injured ligaments. Multiple laser treatments enhanced the collagen growth in the repairing MCLs at 3 weeks after injury, which are superior to a single treatment with similar dosage.
URI: http://hdl.handle.net/10397/34140
ISSN: 0196-8092
DOI: 10.1002/lsm.20077
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