Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/34032
Title: Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo
Authors: Gou, DM
Sun, Y
Gao, L
Chow, LMC 
Huang, J
Feng, YD
Jiang, DH
Li, WX
Issue Date: 2001
Source: Biochimica et biophysica acta. Gene structure and expression, 2001, v. 1518, no. 3, p. 306-310
Abstract: With the aim of identifying genes involved in early human embryonic development. we have isolated a cDNA clone representing a novel human zinc finger gene ZNF268 from 3 week old human embryo cDNA library using a differential hybridization strategy. The complete cDNA sequence of ZNF268 contained an open reading frame of 2841 nucleotides that encodes a 947 amino acid protein with an N-terminal Kruppel-associated box (KRAB) domain and 24 C-terminal zinc fingers. Northern blot analysis showed that ZNF268 mRNA is mainly expressed in 3-5 week old human embryos suggesting it could play certain roles in the embryogenesis. The gene consists of six exons spanning about 22 kb of genomic DNA. According to the genomic sequence from the HTGS database. the ZNF268 gene is assigned to human chromosome 5.
Keywords: Human
Embryo
CDNA
Zinc finger protein
KRAB
Genome structure
Publisher: Elsevier
Journal: Biochimica et biophysica acta. Gene structure and expression 
ISSN: 0167-4781
DOI: 10.1016/S0167-4781(01)00194-4
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