Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33918
Title: Nuclear apoptosis contributes to sarcopenia
Authors: Always, SE
Siu, PM 
Keywords: Atrophy
Mitochondria
Satellite cells
Signaling proteins
Skeletal myofiber
Issue Date: 2008
Publisher: Lippincott Williams & Wilkins
Source: Exercise and sport sciences reviews, 2008, v. 36, no. 2, p. 51-57 How to cite?
Journal: Exercise and Sport Sciences Reviews 
Abstract: Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.
URI: http://hdl.handle.net/10397/33918
ISSN: 0091-6331
DOI: 10.1097/JES.0b013e318168e9dc
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