Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33780
Title: Age-related differences in neural activities during risk taking as revealed by functional MRI
Authors: Lee, TMC
Leung, AWS
Fox, PT
Gao, JH
Chan, CCH 
Keywords: Ageing
Insula
Neuroimaging
Orbitofrontal cortex
Prefrontal cortex
Risk taking
Issue Date: 2008
Source: Social cognitive and affective neuroscience, 2008, v. 3, no. 1, p. 7-15 How to cite?
Journal: Social Cognitive and Affective Neuroscience 
Abstract: Previous research has clearly documented that risky decision making is different in young and older adults. Yet, there has been a relative dearth of research that seeks to understand such age-related changes in the neural activities associated with risk taking. To address this research issue, 21 men (12 young men, mean age 29.9±6.2 years and 9 older men, mean age 65.2±4.2 years) performed a risky-gains task while their brain activities were monitored by an fMRI scanner. The older adults, relative to their younger peers, presented with contralateral prefrontal activity, particularly at the orbitofrontal cortex. Furthermore, stronger activation of the right insula was observed for the older-aged participants compared to the younger-aged adults. The findings of this study are consistent with the a priori speculations established in accordance with the HAROLD model as well as previous findings. Findings of this study suggest that when making risky decisions, there may be possible neuropsychological mechanisms underlying the change in impulsive and risk-taking behaviors during the course of natural ageing.
URI: http://hdl.handle.net/10397/33780
ISSN: 1749-5016
DOI: 10.1093/scan/nsm033
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