Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33704
Title: Role of soluble ceruloplasmin in iron uptake by midbrain and hippocampus neurons
Authors: Ke, Y
Ho, K
Du, J
Zhu, L
Xu, Y
Wang, Q
Wang, CY
Li, L
Ge, X
Chang, Y
Qian, ZM
Keywords: Brain iron homeostasis
Cerulopalsmin
Hippocampus
Iron influx and efflux
Iron-deficient and -sufficient neurons
Midbrain
Issue Date: 2006
Source: Journal of cellular biochemistry, 2006, v. 98, no. 4, p. 912-919 How to cite?
Journal: Journal of Cellular Biochemistry 
Abstract: Ceruloplasmin (CP) is essential for brain iron homeostasis. However, its precise function in brain iron transport has not been definitely determined. In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and the hippocampus. Our data showed that low concentrations of CP (2,4,8 μg/ml) can promote iron influx into iron-deficient neurons, but not the neurons with normal iron status. The same concentrations of CP had no effect on iron efflux from iron-sufficient and normal-iron neurons. Contrary to our expectation, we did not find any regional difference in the effects of CP on iron influx as well as efflux in neurons. The changes in quenching (iron influx) and also dequenching (iron efflux) of intracellular fluorescence, induced by the addition of CP with iron, in the midbrain neurons were no different from those in the hippocampus neurons. The data showed that soluble CP has a role in iron uptake by iron-deficient brain neurons under our experimental conditions. The physiological significance of the results forms the focus for future work.
URI: http://hdl.handle.net/10397/33704
ISSN: 0730-2312
DOI: 10.1002/jcb.20740
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