Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33579
Title: Effects of curvature and cell-cell interaction on cell adhesion in microvessels
Authors: Yan, WW
Liu, Y 
Fu, BM
Keywords: Cell adhesion
Curved microvessel
Lattice Boltzmann method
Issue Date: 2010
Publisher: Springer Heidelberg
Source: Biomechanics and modeling in mechanobiology, 2010, v. 9, no. 5, p. 629-640 How to cite?
Journal: Biomechanics and Modeling in Mechanobiology 
Abstract: It has been found that both circulating blood cells and tumor cells are more easily adherent to curved microvessels than straight ones. This motivated us to investigate numerically the effect of the curvature of the curved vessel on cell adhesion. In this study, the fluid dynamics was carried out by the lattice Boltzmann method (LBM), and the cell dynamics was governed by the Newton's law of translation and rotation. The adhesive dynamics model involved the effect of receptor-ligand bonds between circulating cells and endothelial cells (ECs). It is found that the curved vessel would increase the simultaneous bond number, and the probability of cell adhesion is increased consequently. The interaction between traveling cells would also affect the cell adhesion significantly. For two-cell case, the simultaneous bond number of the rear cell is increased significantly, and the curvature of microvessel further enhances the probability of cell adhesion.
URI: http://hdl.handle.net/10397/33579
DOI: 10.1007/s10237-010-0202-1
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