Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33500
Title: Advanced MR diffusion characterization of neural tissue using directional diffusion kurtosis analysis
Authors: Hui, ES
Cheung, MM
Qi, L 
Wu, EX
Keywords: And orthogonal transformation
Diffusion kurtosis tensor
Directional kurtosis
Restricted diffusion
Issue Date: 2008
Source: Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology", 2008, 4650072, p. 3941-3944 How to cite?
Abstract: MR Diffusion kurtosis imaging (DKI) was proposed recently to study the deviation of water diffusion from Gaussian distribution. Mean kurtosis (MK), directionally averaged kurtosis, has been shown to be useful in assessing pathophysilogical changes. However, MK is not sensitive to kurtosis change occurring along a specific direction. Therefore, orthogonal transformation of the 4 th order kurtosis tensor was introduced in the current study to compute kurtoses along the 3 eigenvector directions of the 2 nd order diffusion tensor. Such axial (K
) and radial (K- ⊥) kurtoses measured the kurtoses along the directions parallel and perpendicular, respectively, to the principal diffusion direction. DKI experiments were performed in normal adult and formalin-fixed rat brain, and developmental brains. The results showed that directional kurtosis analysis revealed different information for tissue characterization.
Description: 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, 20-25 August 2008
URI: http://hdl.handle.net/10397/33500
ISBN: 9781424418152
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