Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33381
Title: Nuclear apoptosis and sarcopenia
Authors: Alway, SE
Siu, PM 
Keywords: Apoptosis
Mitochondria
Muscle atrophy
Nuclear cell death
Satellite cell
Skeletal myofiber
Issue Date: 2011
Publisher: Springer Science+Business Media B.V.
Source: In GS Lynch (Ed.), Sarcopenia- age-related muscle wasting and weakness : mechanisms and treatments, p. 173-206. Dordrecht ; New York: Springer Science+Business Media B.V., 2011 How to cite?
Abstract: Apoptosis is a well-conserve cellular disassembly process, which has been implicated in a variety of diseases. Unlike cells with a single nucleus, apoptotic signaling can target individual nuclei in multi-nucleated skeletal muscle cells without necessarily eliminating the entire cell (muscle fiber). This targeted apoptosis or nuclear apoptosis appears to have a role in regulating aging-induced muscle loss (sarcopenia) by reducing the myofiber volume (i.e. cytoplasm) that can be supported in a single muscle fibre. Recent investigations indicate that apoptotic signaling in aged skeletal muscles occurs through three apoptotic pathways. The intrinsic or mitochondria apoptotic pathway has been most widely studied in muscle. Mitochondria dysfunction and increased mitochondria permeability lead to activation of cysteine-aspartic acid proteases (caspases) and eventually DNA fragmentation in sarcopenia. The death receptor (extrinsic) apoptotic pathway has been strongly implicated in sarcopenia and other conditions of muscle loss with aging or disuse. TNF-α is thought to initiate apoptotic signaling via the death receptor, and this can proceed to activate the effort proteases (e.g., caspase 3) independent from mitochondria signaling. Nevertheless, there is some cross-talk between the intrinsic and the extrinsic apoptotic pathways. Finally, a few studies have shown data to suggest that the endoplasmic reticulum-stress apoptotic pathway may also have a role in sarcopenia, although the importance of this pathway relative to the other two pathways is less clear. Both myonuclei and satellite cells appear to be susceptible to nuclear apoptosis in sarcopenia.
URI: http://hdl.handle.net/10397/33381
ISBN: 9789048197132
9789048197125
DOI: 10.1007/978-90-481-9713-2_9
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