Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33351
Title: Effects of herbal application on the ultrastructural morphology of repairing medial collateral ligament in a rat model
Authors: Fung, DTC
Ng, GYF 
Keywords: Collagen fibril morphology
Healing ligament
Herbal medicine
Rat
Issue Date: 2004
Source: Connective tissue research, 2004, v. 45, no. 2, p. 122-130 How to cite?
Journal: Connective Tissue Research 
Abstract: The present study investigated the effects of an external herbal application on the ultrastructural morphology of repairing medial collateral ligament (MCL) in a rat model. Eight MCL-transected/herb-treated rats (group 1) were compared with 8 MCL-transected/placebo-treated controls (group 2) and 8 MCL-intact/placebo-treated rats (group 3). At 3 and 6 weeks posttransection, MCL specimens were examined under electron microscope. With analysis of 370,709 collagen fibrils, all herb-treated animals had significantly larger fibrils than the controls (p <.001) at 6 weeks postinjury. The mean diameter of those peripheral collagen fibrils of group 1 was larger than the sham group (p <.001). The mass-averaged diameters of group 1 (50.49 to 143.07 nm) and group 3 (59.69 to 188.88 nm) were larger than group 2 (50.59 to 121.94 nm). The area coverage by collagen fibrils ranged from 46.86 to 94.97% for group 1 and 43.70 to 68.08% for group 3 as compared with 40.01 to 50.77% for group 2. Mode obliquity was 0.56 to 0.84 among groups. We concluded that herbal remedy increases collagen fibril size of healing rat MCLs homogeneously at 6 weeks posttransection.
URI: http://hdl.handle.net/10397/33351
ISSN: 0300-8207
DOI: 10.1080/03008200490442662
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