Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33314
Title: Preparation and characterization of quantum dots coated magnetic hollow spheres for magnetic fluorescent multimodal imaging and drug delivery
Authors: Li, L
Li, H
Chen, D
Liu, H
Tang, F
Zhang, Y
Ren, J
Li, Y 
Keywords: Disease diagnosis and therapy
Drug delivery
Hollow
Layer-by-layer
Multimodal imaging
Nanocomposites
Issue Date: 2009
Publisher: American Scientific Publishers
Source: Journal of nanoscience and nanotechnology, 2009, v. 9, no. 4, p. 2540-2545 How to cite?
Journal: Journal of nanoscience and nanotechnology 
Abstract: Innovative nanocomposites of magnetic and fluorescent multifunctional hollow spheres were developed, which combined magnetic resonance imaging (MRI), magnetic targeting, fluorescent imaging (Fl) and drug delivery into one system. Fe 3O 4 hollow spheres were used as templates for the deposition of polyelectrolyte (PE) multilayers and CdTe quantum dots (QDs) via layer-by-layer (LBL) method. The PE multilayers/QDs coated Fe 3O 4 hollow spheres showed high magnetization and fluorescence, which can be used as magnetic and fluorescent multimodal imaging agent in vivo. The multifunctional nanomaterials of polyelectrolyte multilayers/QDs coated Fe 3O 4 hollow spheres were used as controlled drug release system, which showed pH-sensitive drug release over a long time. By combining the multiplexing imaging capability, the magnetic and fluorescent nanocomposites are potential candidates for simultaneous disease diagnosis and therapy.
URI: http://hdl.handle.net/10397/33314
ISSN: 1533-4880 (print)
DOI: 10.1166/jnn.2009.dk04
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