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Title: Effects of low-voltage microamperage stimulation on tendon healing in rats
Authors: Chan, HKF
Fung, DTC
Ng, GYF 
Keywords: Asymmetrical biphasic
Biomechanical testing
Electrical stimulation
Tendon injuries
Issue Date: 2007
Publisher: American Physical Therapy Association, Orthopedic Section
Source: Journal of orthopedic and sports physical therapy, 2007, v. 37, no. 7, p. 399-403 How to cite?
Journal: Journal of orthopedic and sports physical therapy 
Abstract: Fisheye STUDY DESIGN: Randomized controlled prospective experimental study. Fisheye OBJECTIVES: To examine the effects of transcutaneous low-voltage microamperage stimulation (LVMAS) on the mechanical strength of Achilles tendon repair in rats at 4 weeks after injury. Fisheye BACKGROUND: Understanding the effect of LVMAS on the healing of injured tendons is hampered by the lack of related experimental studies, especially from the aspect of biomechanical outcome measures. Fisheye METHODS AND MEASURES: Fourteen 3-month-old male Sprague-Dawley rats received surgical transection to the medial portion of their right Achilles tendon. The rats were divided into a LVMAS group (n = 7) and control group (n = 7). From day 6 postsurgery onwards, the LVMAS group received daily treatment of transcutaneous LVMAS (2.5 V, 100 μA/cm2, 10 pulses per second, positive current) for a total of 22 sessions, while the control group received placebo LVMAS by the same investigator during that period. On day 31, the Achilles tendons were harvested for biomechanical testing for load relaxation, stiffness, and ultimate tensile strength along the longitudinal direction. Fisheye RESULTS: The normalized Achilles tendon ultimate tensile strength of the LVMAS group (mean ± SD, 110.5% ± 25.0%) was higher than that of the control group (75.3% ± 20.8%) (P = .014), but no significant difference was found in normalized stiffness and load relaxation between the 2 groups (P = .239 and .350, respectively). Fisheye CONCLUSION: The results of this study suggest that the administration of transcutaneous LVMAS could improve healing and consequently the tensile strength of partially transected Achilles tendons of rats at 4 weeks after injury.
ISSN: 0190-6011
EISSN: 1938-1344
DOI: 10.2519/jospt.2007.2412
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