Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33017
Title: A remarkably effective copper(II)-dipyridylphosphine catalyst system for the asymmetric hydrosilylation of ketones in air
Authors: Wu, J
Ji, JX
Chan, ASC
Keywords: Asymmetric catalysis
Issue Date: 2005
Publisher: National Academy of Sciences
Source: Proceedings of the National Academy of Sciences of the United States of America, 2005, v. 102, no. 10, p. 3570-3575 How to cite?
Journal: Proceedings of the National Academy of Sciences of the United States of America 
Abstract: The combination of catalytic amounts of optically active dipyridylphosphine and CuF2 along with hydride donor PhSiH3 generated in situ a remarkably reactive catalyst system (substrate-to-ligand molar ratio up to 100,000) for the highly enantioselective hydrosilylation of a broad spectrum of aryl alkyl ketones (up to 97% enantiomeric excess) in normal atmosphere and at mild conditions (ambient temperature to -20°C, compatible with traces of moisture) in the absence of base additives. Furthermore, a highly effective catalytic asymmetric hydrosilylation of unsymmetrical diarylketones using this catalyst system was also realized (up to 98% enantiomeric excess). The Introduction of the dipyridylphosphine ligands in the air-accelerated and inexpensive metal-mediated asymmetric hydrosilylation of ketones makes the present system highly attractive and thus provides an excellent opportunity for practical applications.
URI: http://hdl.handle.net/10397/33017
ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.0409043102
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