Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33006
Title: Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice
Authors: Dai, X
Cui, SG
Li, SR
Chen, Q
Wang, R
Keywords: Deltorphin I
Endomorphin-1
Luzindole
Melatonin
Mice
Tolerance
Issue Date: 2007
Publisher: Elsevier
Source: Behavioural brain research, 2007, v. 182, no. 1, p. 21-27 How to cite?
Journal: Behavioural brain research 
Abstract: The effects of melatonin (Mel) on the development of tolerance to antinociceptive actions induced by mu- and delta-opioid receptor agonists were determined in male Kunming mice. In the mouse tail-flick tests, selective mu and delta receptor agonists were repeatedly administered to mice supraspinally (intracerebroventricularly, i.c.v.) in the absence or presence of melatonin. Administration of endomorphin-1 (EM-1, a mu-opioid receptor agonist) or deltorphin I (del I, a delta-opioid receptor agonist) twice daily for 4 days produced antinociceptive tolerance compared with vehicle controls. Co-administration with melatonin prevented the development of tolerance to deltorphin I analgesia, and this effect was dose dependent. However, melatonin did not affect the development of antinociceptive tolerance to endomorphin-1. Additionally, the attenuation of deltorphin I tolerance by melatonin was reduced by chronic treatment with luzindole (luz), a selective antagonist on the MT2 receptor subtype. Taken together, these data suggest that melatonin interferes with the neural mechanisms involved in the development of tolerance to delta-opioid agonist analgesia via its receptor.
URI: http://hdl.handle.net/10397/33006
ISSN: 0166-4328
EISSN: 1872-7549
DOI: 10.1016/j.bbr.2007.04.018
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