Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32857
Title: Direct analysis of herbal powders by pipette-tip electrospray ionization mass spectrometry
Authors: Wang, H
So, PK
Yao, ZP 
Keywords: Direct analysis
Electrospray ionization
Herbal powder
Mass spectrometry
Pipette tip
Issue Date: 2014
Publisher: Elsevier
Source: Analytica chimica acta, 2014, v. 809, p. 109-116 How to cite?
Journal: Analytica chimica acta 
Abstract: Conventional electrospray ionization mass spectrometry (ESI-MS) is widely used for analysis of solution samples. The development of solid-substrate ESI-MS allows direct ionization analysis of bulky solid samples. In this study, we developed pipette-tip ESI-MS, a technique that combines pipette tips with syringe and syringe pump, for direct analysis of herbal powders, another common form of samples. We demonstrated that various herbal powder samples, including herbal medicines and food samples, could be readily online extracted and analyzed using this technique. Various powder samples, such as Rhizoma coptidis, lotus plumule, great burdock achene, black pepper, Panax ginseng, roasted coffee beans, Fructus Schisandrae Chinensis and Fructus Schisandrae Sphenantherae, were analyzed using pipette-tip ESI-MS and quality mass spectra with stable and durable signals could be obtained. Both positive and negative ion modes were attempted and various compounds including amino acids, oligosaccharides, glycosides, alkaloids, organic acids, ginosensides, flavonoids and lignans could be detected. Principal component analysis (PCA) based on the acquired mass spectra allowed rapid differentiation of closely related herbal species.
URI: http://hdl.handle.net/10397/32857
ISSN: 0003-2670
DOI: 10.1016/j.aca.2013.11.060
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