Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32665
Title: Generation of integration-free neural progenitor cells from cells in human urine
Authors: Wang, L
Wang, L
Huang, W
Su, H
Xue, Y
Su, Z
Liao, B
Wang, H
Bao, X
Qin, D
He, J
Wu, W
So, KF
Pan, G
Pei, D
Issue Date: 2013
Publisher: Nature Publishing Group
Source: Nature methods, 2013, v. 10, no. 1, p. 84-89 How to cite?
Journal: Nature Methods 
Abstract: Human neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs). We combined an episomal system to deliver reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs). These transgene-free hUiNPCs can self-renew and can differentiate into multiple functional neuronal subtypes and glial cells in vitro. Although functional in vivo analysis is still needed, we report that the cells survive and differentiate upon transplant into newborn rat brain.
URI: http://hdl.handle.net/10397/32665
ISSN: 1548-7091
DOI: 10.1038/nmeth.2283
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