Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32532
Title: Brain iron metabolism : neurobiology and neurochemistry
Authors: Ke, Y
Qian, ZM
Issue Date: 2007
Source: Progress in neurobiology, 2007, v. 83, no. 3, p. 149-173
Abstract: New findings obtained during the past years, especially the discovery of mutations in the genes associated with brain iron metabolism, have provided key insights into the homeostatic mechanisms of brain iron metabolism and the pathological mechanisms responsible for neurodegenerative diseases. The accumulated evidence demonstrates that misregulation in brain iron metabolism is one of the initial causes for neuronal death in some neurodegenerative disorders. The errors in brain iron metabolism found in these disorders have a multifactorial pathogenesis, including genetic and nongenetic factors. The disturbances of iron metabolism might occur at multiple levels, including iron uptake and release, storage, intracellular metabolism and regulation. It is the increased brain iron that triggers a cascade of deleterious events, leading to neuronal death in these diseases. In the article, the recent advances in studies on neurochemistry and neuropathophysiology of brain iron metabolism were reviewed.
Keywords: Aging
Brain iron metabolism
Brain iron misregulation
Iron regulatory protein
Iron release proteins
Iron storage proteins
Iron transport proteins
Iron uptake proteins
Neurodegenerative diseases
Publisher: Pergamon-Elsevier Science Ltd
Journal: Progress in Neurobiology 
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2007.07.009
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