Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32445
Title: Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice
Authors: Han, RW
Chang, M
Peng, YL
Qiao, LY
Yin, XQ
Li, W
Wang, R
Keywords: Bead expulsion
Distal colonic transit
Fecal pellet output
Neuropeptide S (NPS)
Neuropeptide S receptor (NPSR)
Issue Date: 2009
Publisher: Elsevier Science Inc
Source: Peptides, 2009, v. 30, no. 7, p. 1313-1317 How to cite?
Journal: Peptides 
Abstract: Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for survival. However, the role of NPS/NPSR system in regulating gastrointestinal motor is still unknown. Here, we studied the effects of NPS on distal colonic transit in mice. Intracerebroventricular (i.c.v.) injection of NPS (1-1000 pmol) inhibited fecal pellet output and bead expulsion in a dose-dependent manner. However, intraperitoneal injection of NPS (1000 and 10 000 pmol) did not affect fecal pellet output and bead expulsion. In vitro, NPS (0.1-10 μM) also did not modulate distal colonic contractions. Furthermore, i.c.v. co-administration of [D-Val5]NPS, a pure and potent NPSR antagonist, dose-dependently antagonized the inhibitory effects of NPS on fecal pellet output and bead expulsion. In conclusion, our results firstly indicate that central NPS inhibits distal colonic transit through the activation of central NPSR, which implicate that NPS/NPSR system might be a new target to treat function disorder of distal colon.
URI: http://hdl.handle.net/10397/32445
DOI: 10.1016/j.peptides.2009.03.012
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

16
Last Week
0
Last month
0
Citations as of Mar 18, 2017

WEB OF SCIENCETM
Citations

16
Last Week
1
Last month
0
Citations as of Mar 18, 2017

Page view(s)

25
Last Week
1
Last month
Checked on Mar 19, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.