Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32297
Title: Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities
Authors: Kok, SHL
Lam, WS
Chan, ASC
Wong, WY
Gambari, R
Wong, RSM
Lee, KKH
Tang, JCO 
Lam, KH
Chui, CH
Issue Date: 2011
Publisher: Royal Soc Chemistry
Source: Medchemcomm, 2011, v. 2, no. 9, p. 881-885 How to cite?
Journal: MedChemComm 
Abstract: In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC 50 < 5 μg ml -1. These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin.
URI: http://hdl.handle.net/10397/32297
DOI: 10.1039/c1md00005e
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