Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32150
Title: Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan
Authors: Hui, PCL 
Wang, WY
Kan, CW 
Zhou, CE
Ng, FSF 
Wat, E
Zhang, VX
Chan, CL
Lau, CBS
Leung, PC
Keywords: Atopic dermatitis
Controlled-release
Cortex Moutan
Microencapsulation
Orthogonal array analysis
Issue Date: 2013
Publisher: Elsevier Science Bv
Source: International journal of biological macromolecules, 2013, v. 55, p. 32-38 How to cite?
Journal: International Journal of Biological Macromolecules 
Abstract: The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio = 1:2; (ii) chitosan concentration = 6% (w/v); (iii) agitation speed = 1100. rpm; and (iv) cross-linking time = 90. min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48. h and the release rate became steady after that.
URI: http://hdl.handle.net/10397/32150
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2012.12.023
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