Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32138
Title: Mechanical properties and in vitro evaluation of bioactivity and degradation of dexamethasone-releasing poly-d-l-lactide/nano-hydroxyapatite composite scaffolds
Authors: Chen, L
Tang, CY 
Tsui, CP 
Chen, DZ
Keywords: Biodegradation
Drug releasing
In vitro bioactivity
Mechanical properties
PDLLA/nano-HAp composites
Issue Date: 2013
Publisher: Elsevier Science Bv
Source: Journal of the mechanical behavior of biomedical materials, 2013, v. 22, p. 41-50 How to cite?
Journal: Journal of the Mechanical Behavior of Biomedical Materials 
Abstract: The purpose of this study was to fabricate drug-release nano-composite scaffolds and perform in vitro evaluation of their mechanical properties, bioactivity, biodegradability and drug release behaviors. Porous drug-release poly-d-l-lactide (PDLLA) composite scaffolds filled with different amounts of nano-hydroxyapatite (nano-HAp) were prepared by a technique combining polymer coagulation, cold compression moulding, salt leaching and drug coating. Apatite detected on the scaffolds after exposure to a simulated body fluid showed improvement in bioactivity and the apatite formation ability through the addition of the nano-HAp content in the composites. Nano-HAp incorporation and apatite formation made a positive impact on the mechanical properties of the scaffolds; however, plasticization and degradation of PDLLA had a negative impact. The pH-compensation effect of the composite scaffolds can reduce the risk of chronic inflammation complications. The fabrication method in this study can produce scaffolds with controllable structure, appropriate mechanical properties and degradation rates for cancellous bone repair applications.
URI: http://hdl.handle.net/10397/32138
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2013.03.008
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