Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32099
Title: Targeting strategies on miRNA-21 and PDCD4 for glioblastoma
Authors: Wang, G
Wang, JJ
Tang, HM
To, SST 
Keywords: Apoptosis
Glioblastoma
miRNA
Oncogenes
Resistance
Signaling pathways
Issue Date: 2015
Publisher: Academic Press
Source: Archives of biochemistry and biophysics, 2015, v. 580, p. 64-74 How to cite?
Journal: Archives of biochemistry and biophysics 
Abstract: MicroRNAs (miRNAs) are often deregulated in glioblastoma multiforme (GBM). Downregulation of microRNA-21 (miR-21), especially in GBM, is responsible for increased apoptosis, decreased cell proliferation and invasion, increased G0/G1 cell cycle arrest, and reduced chemotherapeutic resistance to doxorubicin. Furthermore, it is a critical regulator of multiple downstream genes and signaling pathways involved in gliomagenesis. Programmed cell death 4 (PDCD4) is critical in mediating apoptosis in GBM, and is downregulated by miR-21, which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4. Evidence is mounting that how alterations of these miRNAs transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the roles of miRNAs family members (particularly miR-21 and its target gene PDCD4) in tumors like glioblastoma and new targeting strategies, as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics, to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies.
URI: http://hdl.handle.net/10397/32099
ISSN: 0003-9861
EISSN: 1096-0384
DOI: 10.1016/j.abb.2015.07.001
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

13
Last Week
0
Last month
0
Citations as of Oct 22, 2017

WEB OF SCIENCETM
Citations

14
Last Week
0
Last month
1
Citations as of Oct 18, 2017

Page view(s)

54
Last Week
8
Last month
Checked on Oct 23, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.