Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/32061
Title: Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the South China sea
Authors: Wen, L
Cai, X
Xu, F
She, Z
Chan, WL
Vrijmoed, LLP
Jones, EBG
Lin, Y
Issue Date: 2009
Publisher: American Chemical Society
Source: Journal of organic chemistry, 2009, v. 74, no. 3, p. 1093-1098 How to cite?
Journal: Journal of organic chemistry 
Abstract: Three metabolites, sporothrins A, B, and C (1-3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8- Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis.
URI: http://hdl.handle.net/10397/32061
ISSN: 0022-3263
EISSN: 1520-6904
DOI: 10.1021/jo802096q
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