Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/31958
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | - |
dc.creator | Chu, CHG | - |
dc.creator | Kee, CS | - |
dc.date.accessioned | 2015-07-13T10:34:55Z | - |
dc.date.available | 2015-07-13T10:34:55Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/31958 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2015 Chu, Kee. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication: Chu CHG, Kee CS (2015) Effects of Optically Imposed Astigmatism on Early Eye Growth in Chicks. PLoS ONE 10(2): e0117729 is available at https://doi.org/10.1371/journal.pone.0117729 | en_US |
dc.title | Effects of optically imposed astigmatism on early eye growth in chicks | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0117729 | en_US |
dcterms.abstract | Purpose: To determine the effects of optically imposed astigmatism on early eye growth in chicks. | - |
dcterms.abstract | Methods: 5-day-old (P5) White Leghorn chicks were randomly assigned to either wear, monocularly, a "high magnitude" (H: +4.00DS/-8.00DC) crossed-cylindrical lens oriented at one of four axes (45, 90, 135, and 180; n = 20 in each group), or were left untreated (controls; n = 8). Two additional groups wore a "low magnitude" (L: +2.00DS/-4.00DC) cylindrical lens orientated at either axis 90 or 180 (n = 20 and n = 18, respectively). Refractions were measured at P5 and after 7 days of treatment for all chicks (P12), whereas videokeratography and ex-vivo eyeshape analysis were performed at P12 for a subset of chicks in each group (n = 8). | - |
dcterms.abstract | Results: Compared to controls, chicks in the treatment groups developed significant amounts of refractive astigmatism (controls: 0.03±0.22DC; treatment groups: 1.34±0.22DC to 5.51±0.26DC, one-way ANOVAs, p& le;0.05) with axes compensatory to those imposed by the cylindrical lenses. H cylindrical lenses induced more refractive astigmatism than L lenses (H90 vs. L90: 5.51±0.26D vs. 4.10±0.16D; H180 vs. L180: 2.84 ±0.44D vs. 1.34± 0.22D, unpaired two-sample t-tests, both p& le;0.01); and imposing with-the-rule (H90 and L90) and against-the-rule astigmatisms (H180 and L180) resulted in, respectively, steeper and flatter corneal shape. Both corneal and internal astigmatisms were moderately to strongly correlated with refractive astigmatisms (Pearson's r: +0.61 to +0.94, all p& le;0.001). In addition, the characteristics of astigmatism were significantly correlated with multiple eyeshape parameters at the posterior segments (Pearson's r: -0.27 to +0.45, all p& le;0.05). | - |
dcterms.abstract | Conclusions: Chicks showed compensatory ocular changes in response to the astigmatic magnitudes imposed in this study. The correlations of changes in refractive, corneal, and posterior eyeshape indicate the involvement of anterior and posterior ocular segments during the development of astigmatism. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2015, v. 10, no. 2, e0117729 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2015 | - |
dc.identifier.scopus | 2-s2.0-84922949974 | - |
dc.identifier.pmid | 25675443 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.rosgroupid | 2014000461 | - |
dc.description.ros | 2014-2015 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201811_a bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Chu_optically_imposed_astigmatism.PDF | 4.75 MB | Adobe PDF | View/Open |
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