Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31913
Title: Iron complex-catalyzed N-arylation of pyrazoles under aqueous medium
Authors: Lee, HW
Chan, ASC
Kwong, FY 
Issue Date: 2009
Publisher: Pergamon Press
Source: Tetrahedron letters, 2009, v. 50, no. 42, p. 5868-5871 How to cite?
Journal: Tetrahedron letters 
Abstract: Commercially available FeCl(3)center dot 6H(2)O with conformationally rigid diamine ligand is a highly effective catalyst for N-arylation of pyrazoles using aryl and heteroaryl iodides. It is notable to show that this complex is tolerable under aqueous medium and particularly the whole reaction utilizes water as the sole solvent without any additional organic co-solvents and surfactants. Attempted study using other nitrogen nucleophiles is described. This newly developed system provides an alternative protocol to Cu- and Pd-catalyzed N-arylation reactions.
URI: http://hdl.handle.net/10397/31913
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/j.tetlet.2009.08.018
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