Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31671
Title: A novel porcine dry eye model system (pDEM) with simulated lacrimation/blinking system : preliminary findings on system variability and effect of corneal drying
Authors: Choy, EPY
Cho, P 
Benzie, IFF 
Choy, CKM
To, TSS 
Keywords: Blinking/lacrimation system
Dry eye model
Porcine
Issue Date: 2004
Publisher: Taylor & Francis
Source: Current eye research, 2004, v. 28, no. 5, p. 319-325 How to cite?
Journal: Current eye research 
Abstract: Purpose. To investigate inter- and intra-system variations and the effect of cornea! drying using a recently developed pDEM. Methods. pDEM was used to simulate "normal" and "dry eye" conditions using two "lacrimation-blink" intervals (20 s and 60 s). Corneas were examined/graded with sodium fluorescein before and after the experiment. At the end of each experiment, corneas were assessed by trypan blue exclusion technique. Two duplicated pDEM systems were set up and tested to investigate reproducibility. Results. There was no significant difference in the results produced by the two pDEM systems. In the eyes under "normal" condition, there was no significant increase in the fluorescein grading. However, in eyes under "dry eye" condition, fluorescein staining increased and the number of non-viable cells in the central cornea increased. Conclusions. This novel pDEM system provides a useful assessment tool for the study of causative factors and new treatment strategies for dry eye syndrome.
URI: http://hdl.handle.net/10397/31671
ISSN: 0271-3683
EISSN: 1460-2202
DOI: 10.1076/ceyr.28.5.319.28681
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