Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31645
Title: Electrical assisted patterning of cardiac myocytes with controlled macroscopic anisotropy using a microfluidic dielectrophoresis chip
Authors: Yang, M 
Zhang, X
Keywords: Controlled anisotropy
Dielectrophoresis
Electro-orientation
Microfluidic chip
Issue Date: 2007
Publisher: Elsevier
Source: Sensors and actuators. A, Physical, 2007, v. 135, no. 1, p. 73-79 How to cite?
Journal: Sensors and actuators. A, Physical 
Abstract: Cardiac tissue engineering has evolved as a potential therapeutic approach to assist cardiac regeneration. Controlling the preferential cell orientation of engineered heart tissues is a key issue in cardiac tissue engineering. Here, we present a novel method to construct a model-engineered cardiac tissue-like structure with anisotropic properties. Our analysis shows that the electro-torque which acts on a cylindrical or rod shape cell is zero whenever the electric field is aligned with one of its principal axes. With the interdigitated-castellated microelectrodes, the induction of dielectrophoresis and electro-orientation can accumulate cells and form a tissue-like structure with orientation along the ac electric field. Both experiments and analysis indicate that a large orientation torque and force can be achieved with appropriate frequency and low conductive medium. Finally, we report basic structural and biophysical anisotropy of electro-oriented structure through electromechanical experiments.
URI: http://hdl.handle.net/10397/31645
ISSN: 0924-4247
EISSN: 1873-3069
DOI: 10.1016/j.sna.2006.06.071
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

30
Last Week
0
Last month
0
Citations as of Nov 7, 2017

WEB OF SCIENCETM
Citations

32
Last Week
0
Last month
0
Citations as of Nov 15, 2017

Page view(s)

46
Last Week
1
Last month
Checked on Nov 12, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.