Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31618
Title: Ultrasound phonophoresis of Panax Notoginseng improves the strength of repairing ligament : a rat model
Authors: Ng, GYF 
Wong, RYF
Keywords: Chinese herb
Ligament
Phonophoresis
Tissue biomechanics
Ultrasound
Issue Date: 2008
Publisher: Elsevier
Source: Ultrasound in medicine and biology, 2008, v. 34, no. 12, p. 1919-1923 How to cite?
Journal: Ultrasound in medicine and biology 
Abstract: This study examined the phonophoretic effect of a therapeutic ultrasound coupled with a Panax notoginseng (PN) gel and compared it with a therapeutic ultrasound alone for medial collateral ligament repair in rats. Twenty mature male Sprague-Dawley rats receiving surgical transection to the left medial collateral ligament (MCL) were divided randomly into three groups: ultrasound (US, n = 7), ultrasound with PN coupling gel (PNUS, n = 7) and control (n = 6). The treatments started on day 3 after surgery for six days per week over a two-week period. The US group received 4 min of pulsed ultrasound (1 MHz) at the intensity of 0.5W/cm2 with a normal ultrasonic coupling gel. The PNUS group received the same ultrasound treatment, but with a coupling gel that contained PN extract. The control group received a placebo ultrasound treatment similar to the other two groups. On day 17, the ligaments were mechanically tested for load-relaxation, stiffness and ultimate tensile strength (UTS). Values of the left side were normalized against that of the right side of each animal for analysis. Results revealed significantly higher normalized stiffness (p = 0.009) and UTS (p = 0.022) in the PNUS group than the other two groups, but insignificant difference in load-relaxation among all groups. This study reveals a positive ultrasonic phonophoretic effect of Panax notoginseng extract for improving the strength of ligament repair than ultrasound therapy alone. (E-mail: Gabriel.Ng@inet.polyu.edu.hk).
URI: http://hdl.handle.net/10397/31618
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2008.04.017
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