Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31525
Title: Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart
Authors: Qian, ZM
Chang, YZ
Leung, G
Du, JR
Zhu, L
Wang, Q
Niu, L
Xu, YJ
Yang, L
Ho, KP
Ke, Y
Keywords: Ceruloplasmin
Ferroportin1
Heart
Hephaestin
Iron metabolism
Transferrin receptor
Issue Date: 2007
Publisher: Elsevier
Source: Biochimica et biophysica acta. Molecular basis of disease, 2007, v. 1772, no. 5, p. 527-532 How to cite?
Journal: Biochimica et biophysica acta. Molecular basis of disease 
Abstract: Iron-mediated injury plays an important role in a number of heart disorders. Studies on heart iron are therefore crucial for understanding the causes of excessive heart iron. Heart cells have the ability to accumulate transferrin-bound-iron via the transferrin receptor and non-transferrin-bound-iron probably via the L-type Ca2+ channel and the divalent metal transporter1. However, little is known about the mechanisms of iron export in the heart cells. Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart. We demonstrated that iron has a significant effect on expression of Fpn1 and CP, but not Heph. Treatment of a high-iron diet induced a significant increase in Fpn1, a decrease in CP but no change in Heph mRNA and protein. The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron. The existence of these proteins in the heart implies that they might have a role in heart iron homeostasis.
URI: http://hdl.handle.net/10397/31525
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2007.02.006
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

29
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

26
Last Week
0
Last month
0
Citations as of Aug 20, 2017

Page view(s)

37
Last Week
2
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.