Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/31518
DC Field | Value | Language |
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dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Siu, PM | - |
dc.creator | Yuen, QS | - |
dc.date.accessioned | 2015-07-13T10:33:17Z | - |
dc.date.available | 2015-07-13T10:33:17Z | - |
dc.identifier.issn | 1758-5996 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/31518 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.rights | © 2014 Siu and Yuen; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public DomainDedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,unless otherwise stated. | en_US |
dc.rights | The following publication Siu, P. M., & Yuen, Q. S. (2014). Supplementary use of HbA1c as hyperglycemic criterion to detect metabolic syndrome. Diabetology and Metabolic Syndrome, 6, 119, 1-7 is available at https://dx.doi.org/10.1186/1758-5996-6-119 | en_US |
dc.title | Supplementary use of HbA1c as hyperglycemic criterion to detect metabolic syndrome | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 119 | en_US |
dc.identifier.epage | 7 | - |
dc.identifier.volume | 6 | en_US |
dc.identifier.doi | 10.1186/1758-5996-6-119 | en_US |
dcterms.abstract | Background: Metabolic syndrome (MetS) refers to a cluster of cardiovascular risk factors including hyperglycemia, dyslipidemia, abdominal obesity and hypertension. An effective detection of MetS not only reflects the prediction risk of diabetes mellitus and cardiovascular diseases but also helps to plan for management strategy which could reduce the healthcare burden of the society. This study aimed to compare the use of hemoglobin A1c (HbA1c) to fasting plasma glucose (FPG) as the hyperglycemic component in MetS diagnosis. Methods: Waist circumference, blood pressure, blood triglyceride, high-density lipoprotein (HDL)-cholesterol, FPG, and HbA1c were examined in 120 Hong Kong Chinese adults with MetS and 120 without MetS. After reviewing the subject basal characteristics, 11 of them were found with undiagnosed diabetes (FPG ≧7.0 mmol/L) and were excluded for further analysis. Results: The most prevalent MetS components among the included subjects were elevated systolic blood pressure and central obesity. Significant correlation relationships existed between FPG and HbA1c in both subject pools diagnosed with and without MetS (p < 0.001). The diagnostic rate of MetS using HbA1c was compared to FPG by the receiver operating characteristics (ROC) analysis which suggested an area under curve of 0.807 (95% CI: 0.727 to 0.887). The agreement was 90.7% in MetS-positive group with increased FPG as one of the criterion co-existed with elevated HbA1c. If including HbA1c as an additional criterion to FPG in the MetS diagnosis, 30 more participants in MetS-negative group would be MetS-positive leading to an increase in detection rate. Furthermore, 47 subjects (38 from MetS-positive group and 9 from MetS-negative group) were found having HbA1c ≧6.5%, who would have been diagnosed with diabetes based on the diagnostic criteria implemented by the Expert Group in 2009. Conclusion: These findings suggest that HbA1c enhances the detection of hyperglycemia for the diagnosis of MetS. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Diabetology and Metabolic Syndrome, 2014, v. 6, 119, p. 1-7 | - |
dcterms.isPartOf | Diabetology and Metabolic Syndrome | - |
dcterms.issued | 2014 | - |
dc.identifier.scopus | 2-s2.0-84920825230 | - |
dc.identifier.pmid | 25400701 | - |
dc.identifier.artn | 119 | - |
dc.identifier.rosgroupid | 2014001142 | - |
dc.description.ros | 2014-2015 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Siu_Supplementary_Hba1C_Hyperglycemic.pdf | 286.24 kB | Adobe PDF | View/Open |
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