Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31482
Title: Short- to mid-term effects of ovariectomy on bone turnover, bone mass and bone strength in rats
Authors: Zhang, Y
Lai, WP
Leung, PC
Wu, CF
Wong, MS 
Keywords: Bone mass
Bone strength
Bone turnover
Osteoporosis
Ovariectomy
Issue Date: 2007
Publisher: Pharmaceutical Society of Japan
Source: Biological and pharmaceutical bulletin, 2007, v. 30, no. 5, p. 898-903 How to cite?
Journal: Biological and pharmaceutical bulletin 
Abstract: To determine the short- to mid-term effects of ovariectomy on bone turnover, bone mass and bone strength in rats. SD rats aged 12 weeks were randomly divided into No-treatment, Sham and OVX groups. The rats were sacrificed for sample collection at week 0, week 4 and week 18 after surgical operation. Chemistries in serum and urine were measured by standard colorimetric methods and bone turnover markers were measured by ELISA kits. Bone mass and bone strength were determined using pQCT system and three-point bending tests, respectively. At week 4, OVX rats showed drastic increase in the level of urine Ca, P and DPD. At week 18, in OVX rats the levels of serum ALP, urine DPD and Ca were much higher and the level of serum Ca was much lower when comparing with Sham rats. Ovariectomy produced significant reduction in cancellous BMD, total BMD and SSI of proximal tibial metaphysis rapidly at week 4 and continuously at week 18 after surgical operation. However, no marked changes of bone mass and bone strength were found in the diaphysis of tibia and femur, respectively. The current study concluded that ovariectomy induced the uncoupling of bone turnover, and the proximal metaphysis of long bone was the sensitive site for the short- to mid-term effect of ovariectomy, demonstrated as the markers of bone mass and stress strain index.
URI: http://hdl.handle.net/10397/31482
ISSN: 0918-6158
EISSN: 1347-5215
DOI: 10.1248/bpb.30.898
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