Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31332
Title: Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with £]-lactam antibiotics
Authors: Chan, FY
Sun, N
Leung, YC 
Wong, KY 
Issue Date: 2015
Publisher: Nature Publishing Group
Source: Journal of antibiotics, 2015, v. 68, no. 4, p. 253-258 How to cite?
Journal: Journal of Antibiotics 
Abstract: Filamenting temperature-sensitive mutant Z (FtsZ) is an essential cell division protein that cooperates in the formation of the cytokinetic Z-ring in most bacteria and has thus been recognized as a promising antimicrobial drug target. We have recently used a structure-based virtual screening approach to identify pyrimidine-linked quinuclidines as a novel class of FtsZ inhibitors. In this study, we further investigated the antibacterial properties of one of the most potent compounds (quinuclidine 1) and its synergistic activity with £]-lactam antibiotics. Susceptibility results showed that quinuclidine 1 was active against multiple antibiotic-resistant bacterial strains including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium with minimal inhibit
URI: http://hdl.handle.net/10397/31332
ISSN: 0021-8820
DOI: 10.1038/ja.2014.140
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