Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31244
Title: Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation
Authors: Xiao, J
Yuan, G
Huang, W
Lum, JHK
Lee, KLD
Chan, ASC
Keywords: Analogs of distamycin
DNA cleaving and protecting activities
Issue Date: 2001
Publisher: Chinese Chem Soc
Source: Journal of the Chinese chemical society, 2001, v. 48, no. 5, p. 929-932 How to cite?
Journal: Journal of the Chinese Chemical Society 
Abstract: Two nitrated analogs of distamycin were synthesized by a novel haloform reaction and the DCC/HOBT coupling reaction in a convenient and effective way without amino group protection. Our results have demonstrated that these polyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA damage under short UV (SUV 302 nm).
URI: http://hdl.handle.net/10397/31244
ISSN: 0009-4536
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