Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/31144
Title: Development of miconazole nitrate containing chitosan microcapsules and their anti-Aspergillus niger activity
Authors: Yuen, CWM
Kan, CW 
Cheuk, KL 
Cheung, HC
Cheng, SY
Yip, J 
Lam, PL
Keywords: cell culture
chitosan
controlled release
microencapsulation
Issue Date: 2012
Publisher: Taylor & Francis
Source: Journal of microencapsulation, 2012, v. 29, no. 5, p. 505-510 How to cite?
Journal: Journal of microencapsulation 
Abstract: In this article, we report the development of chitosan/miconazole nitrate microcapsules. Four miconazole nitrate ratios including 12.5, 25, 50 and 100mg were performed in the chitosan-based microencapsulation system. Chitosan microcapsules with the drug input of 25mg showed the highest encapsulation efficiency (52.47) and acceptable mean particle size (5.65m) when compared with those of 12.5, 50 and 100mg. Fourier transform infrared spectroscopic spectrum proved the entrapment of miconazole nitrate into chitosan microcapsules. The antifungal result demonstrated that microcapsules containing 75g miconazole nitrate possessed comparable anti-Aspergillus niger activity as the commercial ointment. The growth inhibition of miconazole nitrate containing chitosan microcapsules towards human skin keratinocytes was found to be dose dependent. A total of 75g of miconazole nitrate containing microcapsules revealed about 25 of growth inhibition while that of 150g showed approximately 70 of growth inhibition. Special monitoring should be taken if a higher dose of miconazole nitrate was used to develop the microcapsules.
URI: http://hdl.handle.net/10397/31144
ISSN: 0265-2048
EISSN: 1464-5246
DOI: 10.3109/02652048.2011.642017
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