Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/30757
Title: A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides
Authors: Xing, QY
Wang, HZ
Zhou, X
Jin, S
Li, YM
Chan, ASC
Issue Date: 2001
Publisher: Hetero Corporation
Source: Journal of heterocyclic chemistry, 2001, v. 38, no. 3, p. 561-567 How to cite?
Journal: Journal of Heterocyclic Chemistry 
Abstract: In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected beta -lactam derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.
URI: http://hdl.handle.net/10397/30757
ISSN: 0022-152X
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