Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/30714
Title: Current and future molecular diagnostics in non-small-cell lung cancer
Authors: Li, CM
Chu, WY
Wong, DL
Tsang, HF
Tsui, NBY
Chan, CML
Xue, VWW
Siu, PMF 
Yung, BYM 
Chan, LWC 
Wong, SCC 
Keywords: ALK rearrangement
EGFR mutation
Molecular diagnostics
Non-small-cell lung cancer
Issue Date: 2015
Publisher: Future Drugs Ltd
Source: Expert review of molecular diagnostics, 2015, v. 15, no. 8, p. 1061-1074 How to cite?
Journal: Expert review of molecular diagnostics 
Abstract: The molecular investigation of lung cancer has opened up an advanced area for the diagnosis and therapeutic management of lung cancer patients. Gene alterations in cancer initiation and progression provide not only information on molecular changes in lung cancer but also opportunities in advanced therapeutic regime by personalized targeted therapy. EGFR mutations and ALK rearrangement are important predictive biomarkers for the efficiency of tyrosine kinase inhibitor treatment in lung cancer patients. Moreover, epigenetic aberration and microRNA dysregulation are recent advances in the early detection and monitoring of lung cancer. Although a wide range of molecular tests are available, standardization and validation of assay protocols are essential for the quality of the test outcome. In this review, current and new advancements of molecular biomarkers for non-small-cell lung cancer will be discussed. Recommendations on future development of molecular diagnostic services will also be explored.
URI: http://hdl.handle.net/10397/30714
ISSN: 1473-7159
EISSN: 1744-8352
DOI: 10.1586/14737159.2015.1063420
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