Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/30395
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dc.contributorSchool of Optometryen_US
dc.creatorLung, JCYen_US
dc.creatorChan, HHLen_US
dc.date.accessioned2015-07-14T01:27:40Z-
dc.date.available2015-07-14T01:27:40Z-
dc.identifier.issn0721-832Xen_US
dc.identifier.urihttp://hdl.handle.net/10397/30395-
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© Springer-Verlag 2010en_US
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology . The final authenticated version is available online at: https://doi.org/10.1007/s00417-010-1346-5.en_US
dc.subjectAdaptationen_US
dc.subjectGlobal flashen_US
dc.subjectLuminanceen_US
dc.subjectMultifocal electroretinogramen_US
dc.titleEffects of luminance combinations on the characteristics of the global flash multifocal electroretinogram (mfERG)en_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1117en_US
dc.identifier.epage1125en_US
dc.identifier.volume248en_US
dc.identifier.issue8en_US
dc.identifier.doi10.1007/s00417-010-1346-5en_US
dcterms.abstractPurpose: This study aims to ascertain the characteristics of the response triggered by the global flash multifocal electroretinogram (MOFO mfERG) under various combinations of global and focal flash luminance, and to determine the optimal conditions for this measurement. Methods: Ten normal subjects with mean age 23.2 yrs (± 1.14 yrs) were recruited for the MOFO mfERG measurement. The visual stimulation consisted of four video frames (stimulus frame with 103 scaled hexagonal focal flashes, followed by a dark frame, a global flash and then another dark frame). The focal and global flash intensities were varied independently for four levels (50, 100, 200 and 400 cd/m 2). The subjects then underwent measurements with sixteen combinations of focal and global flash luminance. The direct component (DC) and induced component (IC) of the MOFO mfERG were grouped into central and peripheral regions for analysis. Results: The central and peripheral DC amplitude increased with the focal flash luminance under constant global flash luminance. Moreover, the proportion of the global flash and focal flash intensity was shown to be important to achieve an optimal IC response. When the ratio of global flash luminance to focal flash luminance (g/f ratio) was kept at about 2:1, the central and peripheral IC amplitude reached the peak value, and further increasing the global flash luminance would not enhance the IC response magnitude. The implicit time of both central and peripheral DC generally decreased with the increase of g/f ratio. However, the implicit time of central and peripheral IC increased with the g/f ratio. Conclusion: The g/f ratio is important in the MOFO mfERG paradigm, since the DC and IC responses change with this ratio. In order to obtain both optimal DC and IC responses, a g/f ratio of 1:1 with focal flash luminance between 100 cd/m 2 and 200 cd/m 2 would be recommended. As the global flash mfERG paradigm is studying the interaction triggered by both flashes, the g/f ratio is a vital parameter for measurement in future studies.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationGraefe's archive for clinical and experimental ophthalmology, Aug. 2010, v. 248, no. 8, p. 1117-1125en_US
dcterms.isPartOfGraefe's archive for clinical and experimental ophthalmologyen_US
dcterms.issued2010-08-
dc.identifier.isiWOS:000279683300009-
dc.identifier.scopus2-s2.0-77955555774-
dc.identifier.pmid20306071-
dc.identifier.eissn1435-702Xen_US
dc.identifier.rosgroupidr50980-
dc.description.ros2010-2011 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0764-n14-
dc.identifier.SubFormID1618-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextRGC: PolyU 5415/06M||Others: GYF32, GU352, J-BB7P, J-BB76en_US
dc.description.pubStatusPublisheden_US
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