Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/30256
Title: Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)
Authors: Chiou, J
Wan, S
Chan, KF 
So, PK
He, D
Chan, EWC
Chan, TH 
Wong, KY 
Tao, J
Chen, S 
Issue Date: 2015
Source: Chemical communications, 2015, v. 51, no. 46, p. 9543-9546
Abstract: We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys221 residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.
Publisher: Royal Society of Chemistry
Journal: Chemical communications 
ISSN: 1359-7345
EISSN: 1364-548X
DOI: 10.1039/c5cc02594j
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